E4

Shop All / Fórmula e4

BESTSELLER ESSENTIALS

Fórmula e4

(Loved by 25+ customers)

Nutrients for a Clear, Even Complexion.

Dietary Supplement based on Vitamin C, Eggshell Membrane, Glutathione, Plant Extracts and Natto Bacteria.

ECM Remodeling Technology 2.0 | Targets Dullness & Texture | EU & cGMP Certified

Size

Purchase options

BUY NOW

fREE DELIVERY-LIMITED TIME ONLY

Core Efficacy

・Promotes Skin Brightness & Even Tone: Formulated with antioxidants and nutrients like Vitamin C and Grape Seed Extract designed to help protect against oxidative stress that can lead to dullness.

・Supports Skin Texture Refinement: Aims to improve the look of skin smoothness and refine the appearance of pores by supporting healthy skin cell renewal.

・Provides Antioxidant Defense: Delivers a blend of antioxidants intended to help shield the skin from environmental aggressors.

・Strengthens Skin’s Foundation: Includes nutrients that play a role in collagen synthesis and extracellular matrix (ECM) health for overall skin resilience.

Ingredients

Active Ingredients:Pureway-C® Powder (Vitamin C), Ovoderm® (Eggshell Membrane), Glutathione, Mangosteen Extract, Beta-glucans, Selenium, Sea Buckthorn Extract, Apple Extract, Klamath Powder, Olive Extract, Saberry® (Amla Extract), Celabio®-F (Rice Bran and Soybean Extract).

Other Ingredients: Vegetarian HPMC Capsule.

Target Audience

・Individuals concerned with dull, uneven, or lackluster skin tone.

・Those seeking to improve skin texture, smoothness, and the appearance of pores.

・People looking for enhanced antioxidant protection from within to complement topical skincare.

・Anyone wanting to support their skin’s overall clarity and radiance.

Suggest Use

As a dietary supplement, take 2 capsules before meal.

Caution

Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Contraindications

・Not recommended for pregnant or breastfeeding women.

・Discontinue use if known hypersensitivity to any ingredient occurs.

・Not intended for use by children.

・This product is a dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Keep out of the reach of children. Store in a cool, dry place. Do not use if safety seal is damaged or missing.

Three Advanced Technologies

One Unified Formula

ECM (Extracellular Matrix) Remodeling Technology 2.0

Targets the skin’s support system – the Extracellular Matrix – which is made of collagen, elastin, and hyaluronic acid.
Provides specific nutrients (L-Proline, L-Lysine, Vitamin C, Copper, MSM) that serve as precursors and cofactors for the body’s own synthesis of these ECM components.
Aims to support the natural renewal and maintenance of a healthy dermal matrix, which is fundamental for smooth, firm, and radiant skin.

Antioxidant Network for Clarity & Defense

Creates a synergistic internal antioxidant shield with Grape Seed Extract (OPCs), Pine Bark Extract (Pycnogenol®), and Vitamin C.
This network is designed to help neutralize free radicals from UV exposure, pollution, and lifestyle factors, which can contribute to skin dullness, uneven tone, and premature aging.

Multi-Mineral Support for Skin Function

Includes Zinc Picolinate, a highly bioavailable form of zinc crucial for skin healing, oil regulation, and antioxidant enzyme function.
Provides Silica, a mineral important for the strength and integrity of connective tissues, supporting skin structure.

Developed to work synergistically at the cellular level.

Rigorous testing that sets a higher standard.

No Preservatives

No Heavy Metals

No Fragrances

No Pigments

No Sweeteners

The Gold Standard in Nutricosmetics

Formula E4 is designed to target dullness and uneven texture at their source, supporting a clear, luminous, and refined complexion from within.

Standard 1

Targeted Efficacy

Features a potent Antioxidant Network (Grape Seed, Pine Bark, Vitamin C) to combat dullness and environmental stress.

Includes key minerals like Zinc and Silica to support skin healing, structure, and overall function.

Standard 2

Pure & Safe

cGMP & EU Certified for unparalleled quality and safety assurance.

Free from artificial additives, common allergens, and harsh ingredients.

Uses a vegetarian HPMC capsule.

Standard 3

High Bioavailability

Utilizes picolinate and gluconate forms of minerals for enhanced absorption.

Features standardized, high-potency botanical extracts to ensure consistent activity and results.

How to use:

As a dietary supplement, take 2 capsules in the morning before breakfast. For optimal support, use daily for 3+ months to align with the skin’s renewal cycle.

Subscribe & Save

Formula E4

Most Popular

ANNUAL

30-day supply • 60 capsules

Frequently Asked Questions

What does “ECM” mean and why is it important?

ECM stands for Extracellular Matrix. It’s the “scaffolding” or support system within your skin, made of collagen, elastin, and hyaluronic acid. A healthy ECM is crucial for firm, plump, smooth, and radiant skin. E4 provides nutrients designed to support your body’s natural ability to maintain and renew this vital matrix.

Can E4 help with acne or blemish-prone skin?

E4 is designed to improve overall skin clarity and texture by supporting antioxidant defenses and a healthy skin matrix. Zinc, in particular, is a nutrient known for its role in skin healing and regulating oil production, which can be beneficial for blemish-prone skin. However, it is not a targeted treatment for acne.

How is E4 different from a Vitamin C serum?

A topical Vitamin C serum works locally on the skin’s surface. E4 works systemically: it provides Vitamin C and other antioxidants that are distributed throughout your body, supporting skin health from the inside out. They are complementary approaches for comprehensive care.

Will E4 make my skin more sensitive to the sun?

No. On the contrary, the antioxidant blend in E4 (Vitamin C, Grape Seed, Pine Bark) is designed to help protect your skin cells from some of the oxidative damage caused by sun exposure. It is not a replacement for topical sunscreen but works as an internal support.

I have sensitive skin. Is E4 suitable for me?

Yes. As an oral supplement, E4 does not come into direct contact with your skin, avoiding topical irritation. The formula is clean and free from common irritants. However, always review the ingredient list if you have specific food or supplement allergies.

Double Nobel Prize-winning research team

SEE ALL SPHYSICIANS

George F Smoot

professor

Nobel Laureates of 2006

Randy W.Schekman

professor

Nobel Laureates of 2013

Javier Cano

professor

Medical Director of Kno Medic, Barcelona

Expert Recommendation

SEE ALL PHYSICIANS

Dra. Claudia Gamazo Laherrán

Verified clinician

Society Secretary

Nuclear Medicine Attending Physician

Years in practice

Protecting the Skin from Oxidative Stress Internally

"Skin radiance is intimately linked to cellular defense against oxidative damage. E4’s blend of high-potency antioxidants like Pureway-C® and glutathione provides direct support for the body's internal protective systems. This helps safeguard skin cells from environmental aggressors, promoting a clearer, more even-toned complexion from within."

Dra. María Gracia Díez Monge

Verified clinician

Clinic Director

Pelvic Floor Physiotherapist

Years in practice

Skin Clarity as a Marker of Internal Health

"The skin often reflects the body's internal state. A formula like E4, which focuses on supporting the skin's extracellular matrix and antioxidant capacity, addresses underlying factors of dullness and uneven texture. For clients committed to a holistic view of health, this represents a smart investment in sustained skin vitality and appearance."

50,000+ verified 5-star reviews for 180 The Concept products

Maya R.

"My skin has always leaned dull and a bit ruddy. E4 was recommended to target that exact issue. I’m 2 months in, and the overall clarity is what strikes me. My complexion looks more even, less blotchy, and has a healthy ‘filtered’ glow. It hasn’t erased my freckles, but they look softer. A fantastic supplement for anyone wanting to brighten from within."

37, Architect

Leo T.

"Sun damage from years outdoors left my skin with uneven tone and roughness. I started E4 hoping to support skin repair. After 3 consistent months, the texture of my skin is noticeably smoother. The old sunspots on my cheeks are lighter, and my skin just reflects light better—it looks healthier, not just tanned. It works subtly but powerfully."

44, Winemaker

Anya K.

"I struggle with congestion and occasional breakouts that leave marks. E4, for me, has been about refining. My skin isn’t perfect, but it looks cleaner, pores appear a bit smaller, and the post-acne redness fades faster. I feel like it’s helping my skin’s natural renewal process. I take it with my morning coffee."

29, Barista

Henry W.

"Age brought a sallow, tired look to my skin. I tried E4 for its antioxidant promise. The change is in the quality of my skin’s appearance. The ‘tired grey’ undertone is gone, replaced by a clearer, more vibrant look. My wife says I look less fatigued, and I agree. It’s a sophisticated product for improving skin’s fundamental radiance."

51, Professor

Sofia M.

"As someone who uses a lot of actives (vitamin C, retinol), I added E4 as a foundational support to enhance my routine and combat environmental stress. My skin seems more resilient, less reactive, and achieves a glow that topical products alone couldn’t give. It’s the internal ‘primer’ that makes everything else perform better."

34, Digital Marketer